The stigma surrounding mental health disorders has disappeared, and now more than ever, people are encouraged to tend to both their physical and mental health. Anxiety, a mental health affliction affecting 19 percent of U.S. adults annually, is at the root of many mental health disorders. Anxiety is characterized by overwhelming feelings of discomfort, fear, stress, and panic that can become debilitating. Recent studies suggest that Cannabidiol (CBD) may play an anxiolytic (anti-anxiety) role in humans and prove to be the future of holistic medicine.
Pharmaceutical research provided initial evidence demonstrating a potential role for CBD in modulating anxiety. Anxiety and fear generally go hand-in-hand, and these studies suggest that CBD interacts with many of the molecular components that regulate fear and anxiety. Interestingly, CBD can interact with a cannabinoid type 1 receptor (CB1R), which helps regulate the release of neurotransmitters, which are responsible for inducing emotions such as fear and anxiety. Increased neurotransmitter regulation using CBD could provide a holistic remedy for anxiety. Additionally, in vivo (in human) pharmacology suggests CBD can bind to another anxiolytic receptor 5-HT1A, further suggesting that CBD may play a role in reducing anxiety.
Along with preliminary pharmacological findings, both pre-clinical and clinical experimentation support the notion that CBD can modulate and relieve anxiety. Pre-clinical studies support prior research that CBD interacts with neurotransmitter and other protein receptors, which ultimately reduce feelings of anxiety, fear, and stress. Many anxiolytic remedies or medications have been proven to induce anxiety when used for prolonged periods. Pre-clinical trials show that unlike other anxiolytic medications, elevated doses of CBD used over long periods does not present these anxiety inducing effects. This makes CBD one of the best holistic and natural remedies for anxiety.
Clinical studies support this preclinical evidence and reinforce the hypothesis that anxiety can be modulated through use of CBD. Experimentally, at dosages between 300 and 600 mg, CBD reduces anxiety in healthy individuals, while leaving baseline anxiety levels unchanged. This means CBD has can inhibit anxiety without inducing these feelings. Also, results in human controls supported an earlier notion that CBD enhances fear extinction, meaning CBD could play a huge role in treatment of PTSD and other mental health illnesses that are treated with Cognitive Behavioral Therapy. Human clinical trials also showed CBD has minimal side-effects, making it one of the safest anxiolytic products on the market.
The abundance of preclinical and clinical results provides exciting evidence that CBD can modulate anxiety and reinforces its potential for treating anxiety-related mental health disorders.
This article was written by the researchers at Green Rock Hemp Holdings based on the following study: Blessing, E. et. al. (2015) Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics (12:825–836). The American Society for Experimental NeuroTherapeutics, Inc.
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